G150

G150 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 10.2 nM for the human enzyme). It is selective for human cGAS over mouse cGAS (IC50 = 25,000 nM). G150 inhibits dsDNA-induced expression of IFNB1 in THP-1 cells and isolated human monocyte-derived macrophages (IC50s = 1.96 and 0.62 µM, respectively) but not LPS-induced expresssion of TNF or poly(I:C)-induced rRNA degradation in the same cells when used at a concentration of 10 µM.Formal Name: 1-[9-(6-amino-3-pyridinyl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-ethanone. CAS Number: 2369751-30-2. Molecular Formula: C18H16Cl2N4O2. Formula Weight: 391.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 234, 301 nm. SMILES: ClC1=CC(C2=CC=C(N)N=C2)=C3C(NC4=C3CN(C(CO)=O)CC4)=C1Cl. InChi Code: InChI=1S/C18H16Cl2N4O2/c19-12-5-10(9-1-2-14(21)22-6-9)16-11-7-24(15(26)8-25)4-3-13(11)23-18(16)17(12)20/h1-2,5-6,23,25H,3-4,7-8H2,(H2,21,22). InChi Key: VVUOUIPXYFIWLE-UHFFFAOYSA-N.