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Item number: TGM-T11344-1mg

Description: G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS). Target: cGAS, DNA. Smiles: Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO. References: Lama L, et al. Development of human...

CAS	2369751-30-2
MW:	391.25 D

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G150

Item number: Cay28318-1

G150 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 10.2 nM for the human enzyme). It is selective for human cGAS over mouse cGAS (IC50 = 25,000 nM). G150 inhibits dsDNA-induced expression of IFNB1 in THP-1 cells and isolated human monocyte-derived macrophages (IC50s = 1.96 and 0.62 µM, respectively) but...

Keywords:	1-[9-(6-amino-3-pyridinyl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-ethanone
Application:	cGAS inhibitor
CAS	2369751-30-2
MW:	391.3 D

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