FTI-277 (hydrochloride)

An FTase inhibitor (IC50 = 0.1 µM), selective for FTase over GGTase (IC50 = >10 µM), inhibits IL-1beta-induced production of NO in primary rat pulmonary artery smooth muscle cells at 10 µM, decreases the proliferation of A549 cells when used at 10 µM and induces cell cycle arrest at the G2/M phase in the same cells at 20 µM, increases the diameter of basilar arteries, improves appetite, and increases activity in a dog model of subarachnoid hemorrhage-induced vasospasm when intracisternally administered. Formulation: A solid. InChI: InChI=1S/C22H29N3O3S2.ClH/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15,/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26),1H/t16-,20+,/m1./s1. InChIKey: PIAFFJUUNXEDEW-PXPMWPIZSA-N. SMILES: N[C@@H](CS)CNC1=CC=C(C(N[C@@H](CCSC)C(OC)=O)=O)C(C2=CC=CC=C2)=C1.Cl