41 products were found matching "K05954"!

A FTase inhibitor (IC50 = 0.083 µM), is selective for FTase over GGTase I, GGTase II, SQS, and MK (IC50s = 26, 47, 516, and >200 µM, respectively), decreases FTase-mediated farnesylation of H-Ras in a cell-free assay. SMILES: C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CNC(C(C([O-])=O)CP([O-])([O-])=O)=O.[Na+].[Na+].[Na+]. InChi...

An FTase inhibitor (IC50 = 0.1 µM), selective for FTase over GGTase (IC50 = >10 µM), inhibits IL-1beta-induced production of NO in primary rat pulmonary artery smooth muscle cells at 10 µM, decreases the proliferation of A549 cells when used at 10 µM and induces cell cycle arrest at the G2/M phase in the same cells...

Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant...

Farnesyltransferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyltransferase...

White to off-white solid. Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. Anticancer compound, Farnesyltransferase inhibitor, Potent anti-inflammatory agent, NF-kappaB inhibitor, Inflammasome inhibitor, Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.

Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It...

Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function...

Arglabin is a sesquiterpene gamma-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities. It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively). Arglabin reduces tumor growth in an SCC-4 mouse...

Isolated from Aspergillus fumigatus. Mycotoxin. Protein farnesyltransferase (PFTase) inhibitor. Anti-cancer compound. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells.

Protein function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. [The UniProt Consortium]

Andrastin A is a meroterpenoid farnesyltransferase inhibitor. It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) (Cay-11764 in multidrug resistant VJ-300 cell culture (the IC50 of vincristine decreased 1.5-20-fold upon treatment with 6.25 µg/ml to 50 µg/ml of of andrastin A),...

Rasfarnesyltransferase inhibitor, Antifungal, antibacterial and herbicidal, Structurally unique natural products, The basic structure of palmarumycin C1 can be modified by a number of hydroxylation, oxygenation, dehydrogenation and chlorination steps. Isolated from Sphaeropsidales sp.