FK-453

FK-453 is an adenosine A1 receptor antagonist (Ki = 18 nM). It is selective for the adenosine A1 receptor over the adenosine A2A and A3 receptors (Kis = 1,300 and 2,800 nM, respectively). FK-453 reduces adenosine-induced negative inotropic activity in isolated guinea pig atrial strips (IC50 = 560 pM).2 It has diuretic activity in rats, where it increases urine volume and sodium excretion when administered at a dose of 10 mg/kg, and reduces cyclosporin-induced nephrotoxicity in rats at 100 mg/kg.. SMILES: O=C(N1[C@H](CCCC1)CCO)/C=C/C2=C(C=CC=C3)N3N=C2C4=CC=CC=C4. InChi Code: InChI=1S/C23H25N3O2/c27-17-14-19-10-4-6-15-25(19)22(28)13-12-20-21-11-5-7-16-26(21)24-23(20)18-8-2-1-3-9-18/h1-3,5,7-9,11-13,16,19,27H,4,6,10,14-15,17H2/b13-12+/t19-/m1/s1. InChi Key: OPLOPFHUHFGKMJ-JXOMPUQVSA-N