F-Amidine (trifluoroacetate salt)

F-Amidine (trifluoroacetate salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10610-100 100 µg -

6 - 10 business days*

32.00€
Cay10610-250 250 µg -

6 - 10 business days*

74.00€
Cay10610-500 500 µg -

6 - 10 business days*

142.00€
Cay10610-1 1 mg -

6 - 10 business days*

250.00€
 
F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and... more
Product information "F-Amidine (trifluoroacetate salt)"
F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4 in vitro, respectively). It irreversibly inactivates all four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1 by covalently modifying an active site cysteine that is important for its catalytic activity. F-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 µM, respectively). Formal Name: N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-benzamide, 2,2,2-trifluoroacetate. CAS Number: 877617-46-4. Molecular Formula: C14H19FN4O2 . CF3COOH. Formula Weight: 408.4. Purity: >95%. Formulation: A solution in methanol. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: FC(F)(C(O)=O)F.NC([C@@H](NC(C1=CC=CC=C1)=O)CCCNC(CF)=N)=O. InChi Code: InChI=1S/C14H19FN4O2.C2HF3O2/c15-9-12(16)18-8-4-7-11(13(17)20)19-14(21)10-5-2-1-3-6-10,3-2(4,5)1(6)7/h1-3,5-6,11H,4,7-9H2,(H2,16,18)(H2,17,20)(H,19,21),(H,6,7)/t11-,/m0./s1. InChi Key: RJYLIKJNBRPBOO-MERQFXBCSA-N. License: Sold under license from the University of South Carolina under U.S. Patent No. 7,964,636.
Keywords: N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-benzamide, 2,2,2-trifluoroacetate
Supplier: Cayman Chemical
Supplier-Nr: 10610

Properties

Application: Peptidyl arginine deiminase (PAD) inhibitor
MW: 408.4 D
Formula: C14H19FN4O2 . CF3COOH
Purity: >95%
Format: Solution

Database Information

CAS : 877617-46-4| Find alternatives
KEGG ID : K01481 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H301+311+331, H370
P Phrases: , P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P303+361+353, P308+311, P321, P370+378, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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