Erlotinib

Erlotinib
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10483-250 250 mg -

6 - 10 business days*

43.00€
Cay10483-500 500 mg -

6 - 10 business days*

77.00€
Cay10483-1 1 g -

6 - 10 business days*

131.00€
Cay10483-5 5 g -

6 - 10 business days*

571.00€
 
Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR... more
Product information "Erlotinib"
Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR autophosphorylation in an HN-5 head and neck cancer mouse xenograft model. Formulations containing erlotinib have been used in the treatment of various cancers.Formal Name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine. CAS Number: 183321-74-6. Synonyms: NSC 718781. Molecular Formula: C22H23N3O4. Formula Weight: 393.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 247, 333 nm. SMILES: C#CC1=CC(NC2=NC=NC3=CC(OCCOC)=C(OCCOC)C=C32)=CC=C1. InChi Code: InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25). InChi Key: AAKJLRGGTJKAMG-UHFFFAOYSA-N.
Keywords: NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
Supplier: Cayman Chemical
Supplier-Nr: 10483

Properties

Application: Tyrosine kinase inhibitor
MW: 393.4 D
Formula: C22H23N3O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 183321-74-6| Matching products
KEGG ID : K04361 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H351, H413
P Phrases: P201, P202, P273, P280, P308+P313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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