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ERB 041 is an estrogen receptor beta (ERbeta) agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively). It is selective for ERbeta over ERalpha (IC50s = 1,200, 620, and 750 nM for human, rat, and mouse ERalpha, respectively). ERB 041 induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERbeta (EC50 = 20 nM). In vivo, ERB 041 (0.1 and 0.3 mg/kg) inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease. It reduces joint swelling in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg. ERB 041 (10 mg/kg) also reduces lesion formation in a mouse model of endometriosis.Formal Name: 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol. CAS Number: 524684-52-4. Molecular Formula: C15H10FNO3. Formula Weight: 271.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml. lambdamax: 216, 247, 309, 338 nm. SMILES: C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1. InChi Code: InChI=1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,18-19H,1H2. InChi Key: MQIMZDXIAHJKQP-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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