Elinogrel

Elinogrel is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 23 nM) that inhibits platelet aggregation in a human platelet-rich plasma (hPRP) assay (IC50 = 2.81 nM). It inhibits thrombosis in a mouse model of vascular injury induced by iron (III) chloride (FeCl3) when administered at a dose of 60 mg/kg.Formal Name: 5-chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide. CAS Number: 936500-94-6. Synonyms: PRT060128, PRT128. Molecular Formula: C20H15ClFN5O5S2. Formula Weight: 523.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: CNC1=C(F)C=C(C(N(C2=CC=C(NC(NS(C3=CC=C(Cl)S3)(=O)=O)=O)C=C2)C(N4)=O)=O)C4=C1. InChi Code: InChI=1S/C20H15ClFN5O5S2/c1-23-15-9-14-12(8-13(15)22)18(28)27(20(30)25-14)11-4-2-10(3-5-11)24-19(29)26-34(31,32)17-7-6-16(21)33-17/h2-9,23H,1H3,(H,25,30)(H2,24,26,29). InChi Key: LGSDFTPAICUONK-UHFFFAOYSA-N.