DWK-1339

DWK-1339 is an inhibitor of amyloid-beta (Abeta) aggregation. It inhibits aggregation of monomeric Abeta (1-42) (Abeta42) and induces disaggregation of Abeta42 fibrils in vitro when used at concentrations ranging from 3.1 to 50 µM. DWK-1339 (10 µM) reduces Abeta42-induced toxicity in HT-22 cells. In vivo, DWK-1339 (10 mg/kg) increases step-through latency in a passive avoidance test and increases spontaneous alteration in the Y-maze compared with vehicle control mice in a mouse model of Abeta42-induced acute Alzheimer's disease. It also decreases brain levels of Abeta42 and increases spontaneous alteration in the Y-maze in the APP/PS1 transgenic mouse model of Alzheimer's disease.Formal Name: 2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-benzofuran. CAS Number: 1018946-38-7. Synonyms: MDR-1339. Molecular Formula: C20H22O4. Formula Weight: 326.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/mL, DMSO: 30mg/mL, Ethanol: 2mg/mL. lambdamax: 214, 315, 329 nm. SMILES: COCCCC1=CC=C2C(C=C(C3=CC(OC)=C(OC)C=C3)O2)=C1. InChi Code: InChI=1S/C20H22O4/c1-21-10-4-5-14-6-8-17-16(11-14)13-19(24-17)15-7-9-18(22-2)20(12-15)23-3/h6-9,11-13H,4-5,10H2,1-3H3. InChi Key: CUEPJIGXQLIOIK-UHFFFAOYSA-N.