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Item number: Cay27642-1

DWK-1339 is an inhibitor of amyloid-beta (Abeta) aggregation. It inhibits aggregation of monomeric Abeta (1-42) (Abeta42) and induces disaggregation of Abeta42 fibrils in vitro when used at concentrations ranging from 3.1 to 50 µM. DWK-1339 (10 µM) reduces Abeta42-induced toxicity in HT-22 cells. In vivo, DWK-1339...

Keywords:	MDR-1339, 2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-benzofuran
Application:	beta-amyloid protein aggregation inhibitor
CAS	1018946-38-7
MW:	326.4 D

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MDR-1339

Item number: TGM-TQ0026-100mg

Description: MDR-1339 (DWK-1339) is an orally active, blood-brain-barrier-permeable inhibitor of amyloid-beta (Abeta) aggregation. Target: Gamma-secretase, Beta Amyloid. Smiles: COCCCc1ccc2oc(cc2c1)-c1ccc(OC)c(OC)c1. References: Ha HJ, et al. Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a...

Keywords:	DWK-1339
Application:	beta-amyloid protein aggregation inhibitor
CAS	1018946-38-7
MW:	326.39 D

From 51.00€ *

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