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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay28536-1 | 1 mg | - |
6 - 10 business days* |
270.00€
|
|||
Cay28536-5 | 5 mg | - |
6 - 10 business days* |
1,209.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Disulfiram-d20 is intended for use as an internal standard for the quantification of disulfiram... more
Product information "Disulfiram-d20"
Disulfiram-d20 is intended for use as an internal standard for the quantification of disulfiram (Cay-15303) by GC- or LC-MS. Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM). It also inhibits the copper-dependent enzyme dopamine beta-hydroxylase, which prevents the breakdown of dopamine. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 µM) and 26S proteasome (IC50 = 20 µM) from MDA-MB-0231 breast cancer cells. Disulfiram (at 250 nM) induces reactive oxygen species, activates JNK and p38 pathways, and inhibits NF-kappaB activity, which suppresses self-renewal in cancer stem cells.Formal Name: bis(1,1,2,2,2-pentadeuterioethyl)carbamothioylsulfanyl N,N-bis(1,1,2,2,2-pentadeuterioethyl)carbamodithioate. CAS Number: 1216403-88-1. Synonyms: Tetraethylthiuram disulfide-d20. Molecular Formula: C10D20N2S4. Formula Weight: 316.7. Purity: >99% deuterated forms (d1-d20). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Methanol: soluble. SMILES: S=C(N(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])SSC(N(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])=S. InChi Code: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3/i1D3,2D3,3D3,4D3,5D2,6D2,7D2,8D2. InChi Key: AUZONCFQVSMFAP-DEHFLJNXSA-N.
Keywords: | Tetraethylthiuram disulfide-d20, bis(1,1,2,2,2-pentadeuterioethyl)carbamothioylsulfanyl N,N-bis(1,1,2,2,2-pentadeuterioethyl)carbamodithioate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 28536 |
Properties
Application: | GC-MS, LC-MS, Internal standard, Quantification, aldehyde dehydrogenase inhibitor |
MW: | 316.7 D |
Formula: | C10D20N2S4 |
Purity: | >99% deuterated forms (d1-d20) |
Format: | Solid |
Database Information
CAS : | 1216403-88-1| Matching products |
KEGG ID : | K00128 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H317, H373 |
P Phrases: | P260, P261, P264, P270, P272, P280, P301+310, P302+352, P314, P321, P330, P333+313, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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