Dimethylenastron

Dimethylenastron is an inhibitor of the mitotic kinesin Eg5 (IC50 = 200 nM in an ATPase assay). It is selective for Eg5 over other kinesin subfamilies from four different organisms. Dimethylenastron induces accumulation of HeLa cells in the G2/M phase (75% at a concentration of 1 µM). It inhibits spindle formation and induces radial arrangement of chromosomes in Xenopus oocytes. Dimethylenastron inhibits migration and growth of PANC-1 pancreatic cancer cells in a concentration-dependent manner. Dimethylenastron also inhibits angiogenesis and induces severe circulation defects in zebrafish embryos.Formal Name: 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone. CAS Number: 863774-58-7. Molecular Formula: C16H18N2O2S. Formula Weight: 302.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 324 nm. SMILES: O=C1CC(C)(C)CC2=C1C(C3=CC(O)=CC=C3)NC(N2)=S. InChi Code: InChI=1S/C16H18N2O2S/c1-16(2)7-11-13(12(20)8-16)14(18-15(21)17-11)9-4-3-5-10(19)6-9/h3-6,14,19H,7-8H2,1-2H3,(H2,17,18,21). InChi Key: RUOOPLOUUAYNPY-UHFFFAOYSA-N.