Derazantinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase... more
Product information "Derazantinib"
Description: Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor with IC50 values of 4.5/1.8/4.35/3.4 nM for chondrocyte FGFR1/FGFR2/FGFR3/FGFR4, respectively. Target: FGFR. Smiles: COCCNCCc1cccc(Nc2ncc3C[C@@H](c4ccccc4F)c4ccccc4-c3n2)c1. References: Balek L, et al. ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFRBone. 2017 Dec,105:57-66.
| Keywords: | ARQ-087 |
| Supplier: | TargetMol |
| Supplier-Nr: | TQ0228 |
Properties
| Application: | Multi-kinase inhibitor |
| MW: | 468.57 D |
| Formula: | C29H29FN4O |
Database Information
| CAS : | 1234356-69-4| Matching products |
| KEGG ID : | K05093 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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