- Search results for K05093
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90 products were found matching "K05093"!
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Item number: NSJ-RQ7172
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Fibroblast growth factor receptor 2 (FGFR2) is a receptor for fibroblast growth factor encoded on a gene residing on chromosome 10. FGFR2 has also been designated as CD332. FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for...
Keywords: | Anti-BEK, Anti-KGFR, Anti-FGFR2, Anti-K-sam, Anti-CD332, Anti-FGFR-2, Anti-Keratinocyte growth factor receptor,... |
Application: | WB, IHC (paraffin), FC, Direct ELISA |
Host: | Rabbit |
Species reactivity: | human |
755.00€
*
Item number: ELK-ELK3090.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FGFR2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FGFR2. Next,...
Keywords: | BEK, KGFR, FGFR2, K-sam, CD332, FGFR-2, Keratinocyte growth factor receptor, Fibroblast growth factor receptor 2 |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: BPS-40211
Active human FGFR2 (GenBank Accession No. NM_000141), (a.a. 399-end) with N-terminal GST tag, MW= 74 kDa, expressed in baculovirus expression system. Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA, 0.01% BRIJ- 35 and...
Keywords: | BEK, KGFR, K-sam, FGFR2, CD332, FGFR-2, Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor, |
Application: | Enzyme kinetics, inhibitor screening |
MW: | 74 kD |
555.00€
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Item number: Cay20843-25
LY2874455 is a pan-inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases with IC50 values of 2.8, 2.6, 6.4, 6, and 7 nM for FGFR1, FGFR2, FGFR3, FGFR4, and VEGFR2, respectively. It has been shown to inhibit proliferation of KMS-11, OPM-2, SNU-16, and KATO-III cancer cells in vitro and in tumor...
Keywords: | 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol |
Application: | FGFR inhibitor |
CAS | 1254473-64-7 |
MW: | 444.3 D |
From 100.00€
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Item number: Cay13032-10
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50...
Keywords: | N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
Application: | FGFR inhibitor |
CAS | 219580-11-7 |
MW: | 523.7 D |
From 53.00€
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Item number: Cay13111-5
AZD 4547 is a selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase with IC50 values of 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively. It displays weaker activity against FGFR4 (IC50 = 165 nM), VEGFR2 (IC50 = 24 nM), and a panel of other tyrosine and serine/theronine kinases...
Keywords: | rel-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-benzamide |
Application: | FGFR inhibitor |
CAS | 1035270-39-3 |
MW: | 463.6 D |
From 147.00€
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Item number: Cay21813-1
JNJ-42756493 is a pan-FGFR inhibitor (IC50s = 1.2, 2.5, 3, and 5.7 nM for FGFR1, -2, -3, and -4, respectively). It is selective for FGFRs over VEGFR2 (IC50 = 36.8 nM). JNJ-42756493 inhibits the proliferation of Ba/F3 cells expressing FGFR1, -3, or -4 (IC50s = 22.1, 13.2, and 25 nM, respectively). It reduces tumor...
Keywords: | Erdafitinib, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine |
Application: | FGFR inhibitor |
CAS | 1346242-81-6 |
MW: | 446.6 D |
From 42.00€
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Item number: Cay19837-1
FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1...
Keywords: | N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)... |
Application: | FGFR inhibitor |
CAS | 1633044-56-0 |
MW: | 634.7 D |
From 60.00€
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Item number: Cay31754-5
Alofanib is an allosteric inhibitor of FGFR2. It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2alpha) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF, IC50 = 11...
Keywords: | RPT835, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-benzoic acid |
Application: | Allosteric FGFR2 inhibitor |
CAS | 1612888-66-0 |
MW: | 413.4 D |
From 115.00€
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Item number: Cay33787-1
PRN-1371 is an irreversible covalent pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively). It is selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit colony stimulating factor 1 receptor (CSF1R) activity by...
Keywords: | 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]propyl]-pyrido[2,3-d]pyri... |
Application: | Irreversible pan-FGFR inhibitor |
CAS | 1802929-43-6 |
MW: | 561.5 D |
From 94.00€
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Item number: ARG64673.100
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning,...
Keywords: | Anti-BEK, Anti-KGFR, Anti-FGFR2, Anti-K-sam, Anti-CD332, Anti-FGFR-2, EC=2.7.10.1, Anti-Keratinocyte growth factor... |
Application: | ELISA, WB |
Host: | Goat |
Species reactivity: | human |
784.00€
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Item number: G-HUFI02459.96
Application: | ELISA |
Species reactivity: | human |
641.00€
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