191 products were found matching "K05093"!

Product Description: Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane protein that spans the cell membrane with one end inside the cell and the other projecting from the outer surface. It functions as a receptor for fibroblast growth factors, triggering chemical reactions that regulate critical...

Product Description: Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane protein that spans the cell membrane with one end inside the cell and the other projecting from the outer surface. It functions as a receptor for fibroblast growth factors, triggering chemical reactions that regulate critical...

Product Description: Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane protein that spans the cell membrane with one end inside the cell and the other projecting from the outer surface. It functions as a receptor for fibroblast growth factors, triggering chemical reactions that regulate critical...

Recombinant human FGFR2b (fibroblast growth factor receptor 2b), encompassing amino acids 22-378. This construct contains a C-terminal Avi-tag followed by a His-tag (6xHis). This protein is enzymatically biotinylated using Avi-Tag(TM) technology and affinity purified. FGFR2 (Fibroblast Growth Factor Receptor 2) is a...

Recombinant human FGFR2b (fibroblast growth factor receptor 2b), encompassing amino acids 22-378. This construct contains the Fc domain of IgG1 on the C-terminus, followed by an Avi-Tag. This protein is enzymatically biotinylated using Avi-Tag(TM) technology and affinity purified. FGFR2 (Fibroblast Growth Factor...

This anti-FGFR2b (Fibroblast growth factor receptor 2b) antibody is a purified, recombinant human IgG1 monoclonal antibody that recognizes human FGFR2b. This antibody is similar to Bemarituzumab. Bemarituzumab is commercially available for the treatment of advanced gastric and gastroesophageal junction (GEJ)...

This anti-TGF beta (tumor growth factor) antibody is a purified, recombinant human IgG4 monoclonal antibody that recognizes human TGF beta. This antibody is similar to Fresolimumab. Fresolimumab is under investigation for the treatment of NSCLC (non-small cell lung cancer). The TGFbeta (tumor growth factor beta)...

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb...

Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning,...

Active human FGFR2 (GenBank Accession No. NM_000141), (a.a. 399-end) with N-terminal GST tag, MW= 74 kDa, expressed in baculovirus expression system. Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA, 0.01% BRIJ- 35 and...

LY2874455 is a pan-inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases with IC50 values of 2.8, 2.6, 6.4, 6, and 7 nM for FGFR1, FGFR2, FGFR3, FGFR4, and VEGFR2, respectively. It has been shown to inhibit proliferation of KMS-11, OPM-2, SNU-16, and KATO-III cancer cells in vitro and in tumor...

The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50...