DCPIB

DCPIB is an inhibitor of volume-regulated anion channels (VRAC). It inhibits the swelling-induced chloride current (ICl,swell) in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM). DCPIB inhibits the VRAC subunit leucine-rich containing 8A (LRRC8A, IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced cGAMP uptake by LRRC8A in telomerase-immortalized human microvascular endothelial (TIME) cells when used at a concentration of 20 µM. It also inhibits the two-pore domain potassium channels K2P18.1/TRESK, K2P3.1/TASK1, and K2P9.1/TASK3 in COS-7 cells expressing the human channels (IC50s = 0.14, 0.95, and 50.72 µM, respectively). DCPIB (10 µM) activates K2P2.1/TREK1 and K2P4.1/TRAAK channels in COS-7 cells expressing the human channels. Intracisternal administration of DCPIB (20 µg/kg) reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).Formal Name: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-butanoic acid. CAS Number: 82749-70-0. Molecular Formula: C22H28Cl2O4. Formula Weight: 427.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 225, 272 nm. SMILES: O=C(CCCOC1=C(Cl)C(Cl)=C(C(C(CCCC)(C2CCCC2)C3)=O)C3=C1)O. InChi Code: InChI=1S/C22H28Cl2O4/c1-2-3-10-22(15-7-4-5-8-15)13-14-12-16(28-11-6-9-17(25)26)19(23)20(24)18(14)21(22)27/h12,15H,2-11,13H2,1H3,(H,25,26). InChi Key: KHKGTPJPBOQECW-UHFFFAOYSA-N.