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dBRD9 is a proteolysis-targeting chimera (PROTAC) composed of a bromodomain-containing protein 9 (BRD9) inhibitor conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877) via an alkyl ether linker. It selectively degrades BRD9 over BRD4 and BRD7 at 100 nM and reduces the proliferation of MOLM-13 leukemia cells in a concentration-dependent manner.. SMILES: O=C(NC(CC1)=O)C1N2C(C3=C(C=CC=C3NCCOCCOCCNC(CN(CC4=C(OC)C=C(C5=CN(C)C(C6=C5C=CN=C6)=O)C=C4OC)C)=O)C2=O)=O. InChi Code: InChI=1S/C40H45N7O10/c1-45(21-29-32(54-3)18-24(19-33(29)55-4)28-22-46(2)38(51)27-20-41-11-10-25(27)28)23-35(49)43-13-15-57-17-16-56-14-12-42-30-7-5-6-26-36(30)40(53)47(39(26)52)31-8-9-34(48)44-37(31)50/h5-7,10-11,18-20,22,31,42H,8-9,12-17,21,23H2,1-4H3,(H,43,49)(H,44,48,50). InChi Key: AIOCFZJGGGEWDK-UHFFFAOYSA-N
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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