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dBRD9
Item number: Cay45720-1
dBRD9 is a proteolysis-targeting chimera (PROTAC) composed of a bromodomain-containing protein 9 (BRD9) inhibitor conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877) via an alkyl ether linker. It selectively degrades BRD9 over BRD4 and BRD7 at 100 nM and reduces the proliferation of MOLM-13 leukemia...
| Keywords: | 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-diox... |
| Application: | BRD9 degradation driving PROTAC |
| CAS | 2170679-45-3 |
| MW: | 783.84 D |
From 153.00€
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dBRD9
Item number: TGM-T31221-100mg
Description: dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is...
| Keywords: | dBRD-9, dBRD 9 |
| CAS | 2170679-45-3 |
| MW: | 783.83 D |
From 123.00€
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dBRD9
Item number: BPS-84081-1
dBRD9 is a PROTAC (proteolysis targeting chimera) that can selective degrade BRD9 (Bromodomain containing 9). dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET (bromodomain and extra-terminal) family. CRBN (cereblon) is the substrate-binding component of the E3...
| Application: | BRD9 PROTAC studies |
| CAS | 2170679-45-3 |
| MW: | 783.83 D |
From 996.00€
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