Cyclopiazonic Acid

Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = 0.6 µM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.Formal Name: 10-acetyl-2,6,6aR,7,11aS,11bR-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one. CAS Number: 18172-33-3. Synonyms: CPA, NSC 117181. Molecular Formula: C20H20N2O3. Formula Weight: 336.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 224, 281 nm. SMILES: CC1(C)N2[C@@](C(O)=C(C(C)=O)C2=O)([H])[C@@]([C@@]1([H])C3)([H])C4=CNC5=CC=CC3=C54. InChi Code: InChI=1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,24H,7H2,1-3H3/t12-,16+,17+/m1/s1. InChi Key: SZINUGQCTHLQAZ-DQYPLSBCSA-N.