Description: Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase, SERCA)nanomolar inhibitor and a potent inducer of cell death in plants. Target: Calcium Channel. Smiles:...

Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = 0.6 µM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg),...

An inhibitor of the sarco/endoplasmic reticulum calcium pump that has produced hypokinesia, hypothermia, catalepsy, ptosis, and sedation without loss of righting reflex, tremor, gait disturbance, dyspnoea, opisthotonus, atypical convulsion, and prolonged barbiturate-induced sleep in mice.