CU CPT 22

CU CPT 22 is an antagonist of toll-like receptor 1 (TLR1) and TLR2 heterodimers (TLR1/TLR2, Ki = 0.41 µM). It inhibits nitric oxide (NO) production induced by the TLR2 agonist Pam3CSK4 (Cay-24126) in RAW 264.7 cells (IC50 = 0.58 µM). It is selective for TLR1/TLR2 over TLR2/TLR6 and TLR3, -4, and -7 homodimers, as well as 10 kinases at 0.5 µM. CU CPT 22 (8 µM) inhibits Pam3CSK4-induced release of TNF-alpha and IL-1beta in RAW 264.7 cells by 60 and 95%, respectively.Formal Name: 3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid, hexyl ester. CAS Number: 1416324-85-0. Molecular Formula: C19H22O7. Formula Weight: 362.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMSO: Soluble. lambdamax: 309, 403 nm. SMILES: COC1=CC(C=C(C(OCCCCCC)=O)C=C(O)C2=O)=C2C(O)=C1O. InChi Code: InChI=1S/C19H22O7/c1-3-4-5-6-7-26-19(24)12-8-11-10-14(25-2)17(22)18(23)15(11)16(21)13(20)9-12/h8-10,22-23H,3-7H2,1-2H3,(H,20,21). InChi Key: UBQFTTUFRSSOHE-UHFFFAOYSA-N.