Colchicine

Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 µM) that binds to tubulin, which disrupts spindle formation during mitosis. It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 µmol/kg in a mouse model of gout and preventing the deposition of uric acid.Formal Name: N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide. CAS Number: 64-86-8. Molecular Formula: C22H25NO6. Formula Weight: 399.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. lambdamax: 202, 243, 352 nm. SMILES: COC1=C(OC)C=C2C(C(C([C@@H](NC(C)=O)CC2)=C3)=CC=C(OC)C3=O)=C1OC. InChi Code: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1. InChi Key: IAKHMKGGTNLKSZ-INIZCTEOSA-N.