CHMFL-FLT3-122

Item number	Size	Manual	Delivery time	Price
Cay43137-1	1 mg	-	6 - 10 business days*	89.00€
Cay43137-5	5 mg	-	6 - 10 business days*	423.00€
Cay43137-10	10 mg	-	6 - 10 business days*	623.00€

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CHMFL-FLT3-122 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 40 nM). It is... more

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Product information "CHMFL-FLT3-122"

CHMFL-FLT3-122 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 40 nM). It is selective for FLT3 over Bruton's tyrosine kinase (BTK) and C-Kit (IC50s = 421 and 559 nM, respectively) and a panel of 468 additional kinases at 1 µM. CHMFL-FLT3-122 inhibits the growth of MV4-11, MOLM-13, and MOLM-14 acute myeloid leukemia (AML) cells containing FLT3 bearing an internal-tandem duplication (FLT3-ITD, GI50s = 22, 21, and 42 nM, respectively). In vivo, CHMFL-FLT3-122 (50 mg/kg) inhibits tumor growth in an MV4-11 mouse xenograft model.. Solulibility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml: DMSO: Slightly soluble: 0.1-1 mg/ml.

Keywords:	HYML-122, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone
Supplier:	Cayman Chemical
Supplier-Nr:	43137

Properties

Application:	FMS-related tyrosine kinase 3 (FLT3) inhibitor
MW:	471.57 D
Formula:	C26H29N7O2
Purity:	>95%
Format:	Solid

Database Information

CAS :	1839150-56-9\| Matching products
KEGG ID :	K05092 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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