Cevipabulin

Cevipabulin is an activator of microtubule polymerization. It induces aggregation of isolated bovine brain tubulin in a concentration-dependent manner. Cevipabulin (100 µM) inhibits binding of vinblastine (Cay-11762), but not colchicine (Cay-9000760), to tubulin in cell-free assays. It induces mitotic block in HeLa cells when used at a concentration of 68 nM and is cytotoxic to MDA-MB-468, MDA-MB-435, LNCaP, SKOV3, and HeLa cancer cell lines (IC50s = 18-40 nM). Cevipabulin (20 mg/kg, i.v.) reduces tumor growth in a LoVo colon adenocarcinoma mouse xenograft model.Formal Name: 5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine. CAS Number: 849550-05-6. Synonyms: TTI-237. Molecular Formula: C18H18ClF5N6O. Formula Weight: 464.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 224, 297 nm. SMILES: FC(F)(F)[C@H](C)NC1=C(C2=C(C=C(C=C2F)OCCCNC)F)C(Cl)=NC3=NC=NN31. InChi Code: InChI=1S/C18H18ClF5N6O/c1-9(18(22,23)24)28-16-14(15(19)29-17-26-8-27-30(16)17)13-11(20)6-10(7-12(13)21)31-5-3-4-25-2/h6-9,25,28H,3-5H2,1-2H3/t9-/m0/s1. InChi Key: ZUZPCOQWSYNWLU-VIFPVBQESA-N.