Cerestat

Cerestat is an NMDA receptor antagonist (IC50 = 36 nM). It is selective for the NMDA receptor over sigma receptors (IC50 = 2,540 nM). Cerestat (1 mg/kg) reduces infarct volume and the number of steps and errors in a foot fault test in a rat model of stroke induced by middle cerebral artery occlusion. It also reduces cortical and striatal neuronal necrosis in a rat model of temporary focal ischemia when administered at a dose of 1.13 mg/kg.Formal Name: N-(3-ethylphenyl)-N-methyl-N'-1-naphthalenyl-guanidine, monohydrochloride. CAS Number: 137160-11-3. Synonyms: CNS 1102. Molecular Formula: C20H21N3 . HCl. Formula Weight: 339.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 50 mM. SMILES: N=C(N(C)C1=CC(CC)=CC=C1)NC2=CC=CC3=C2C=CC=C3.Cl. InChi Code: InChI=1S/C20H21N3.ClH/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19,/h4-14H,3H2,1-2H3,(H2,21,22),1H. InChi Key: CKAKVKWRMCAYJD-UHFFFAOYSA-N.