137 products were found matching "K05208"!

Lanicemine is a low-trapping NMDA receptor antagonist (IC50 = 9. µM) and an active metabolite of BHV 5000. Intraperitoneal administration of lanicemine prevents seizures induced by maximal electroshock, 4-aminopyridine (Cay-18511), N-methyl-DL-aspartate, or kainic acid in mice (ED50s = 13, 17. 54, and ~50 mg/kg,...

CGP 37849 is an NMDA receptor antagonist (Ki = 220 nM). It decreases the number of seizures induced by maximal electroshock (MES) in rats (ED50 = 21 mg/kg). CGP 37849 (0.62, 1.25, or 2.5 mg/kg) reduces immobility time in the forced swim test. SMILES O=P(O)(O)C/C(C)=C/C(N)C(O)=O InChi Code...

SDZ 220-040 is an NMDA receptor antagonist (apparent pA2 = 8.75). It reduces the number of convulsions induced by maximal electroshock (MES) in mice (ED50 = 3.2-10 mg/kg). SMILES ClC1=C(C=CC(Cl)=C1)C2=CC(C[C@H](N)C(O)=O)=C(C(CP(O)(O)=O)=C2)O InChi Code...

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 µM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (-)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been...

Anti-NMDA NR1 Subunit antibody is directed against rat NMDA NR1 subunit protein. The antibody was clarified from tissue culture supernatant. Reactivity is expected in rat and mouse. Cross reactivity with NMDA NR1 receptor from other species has not been determined. Protein function: NMDA receptor subtype of...

MK-801 is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) (Cay-14581) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux. It has been shown to be protective in various models of ischemia as well as to inhibit...

Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 µM. It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A)...

Kynurenic acid is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via a kynurenine (Cay-11305) intermediate by kynurenine aminotransferases (KATs). Kynurenic acid is an antagonist of the NMDA and AMPA receptors as well as alpha7 nicotinic acetylcholine receptors (nAChRs, EC50s...

Kynurenic acid-d5 is intended for use as an internal standard for the quantification of kynurenic acid (Cay-16792) by GC- or LC-MS. Kynurenic acid is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via a kynurenine (Cay-11305) intermediate by kynurenine aminotransferases...

NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate. Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity. Repetitive activation of NMDA synapses leads to long-term...

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses,...

Synthetic. Chemical. CAS: 1783-96-6. Formula: C4H7NO4. MW: 133.1. Synthetic. Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous...