CC-885

CC-885 is a modulator of Cereblon and known degrader of GSPT1 (G1 to S phase transition 1). GSPT1 (G1 to S phase transition 1), also known as eRF3a, is an essential translation-termination factor that became a key substrate for cereblon (CRNB)-based molecular glues (MGs) such as CC-885 and CC-90009. These compounds bind cereblon and trigger the E3 ligase to recruit and ubiquitinate GSPT1, leading to its rapid proteasomal degradation. Cereblon is the substrate-binding component of the E3 protein ligase complex DDB1 (damage specific DNA binding protein 1)-CUL4A (cullin 4)-RBX1 (ring-box 1), which is involved in the ubiquitination and proteasomal degradation of target proteins. CRBN has become a target of choice for the development of many PROTACs (proteolysis targeting chimera) with therapeutical interest. Loss of GSPT1 disrupts translational fidelity and induces strong antiproliferative effects, particularly in AML (acute myeloid lymphoma) and other sensitive cancer types. As a result, GSPT1 is now considered a high-value target in the field of targeted protein degradation (TPD). The development of these molecular glues and PROTACS opens new avenues in cancer therapy. CC-885 is a modulator of Cereblon and known degrader of GSPT1.