Carbinoxamine (maleate)

Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine. It also competes with [3H]diltiazem, an L-type calcium channel blocker, for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM). Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM) and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively) by 48% compared with control. Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.Formal Name: 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-ethanamine, (2Z)-2-butenedioate. CAS Number: 3505-38-2. Synonyms: NSC 62362. Molecular Formula: C16H19ClN2O . C4H4O4. Formula Weight: 406.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CN(C)CCOC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13,5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: GVNWHCVWDRNXAZ-BTJKTKAUSA-N.