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Description: C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. Target: STING. Smiles: [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2c(c1)oc1ccccc21. References: Haag S M , Gulen M F , Luc R , et al. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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