BYK204165

BYK204165 is a selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay). It is selective for PARP1 over PARP2 (IC50 = 4,168 nM for murine PARP2 in an enzyme assay). BYK204165 inhibits hydrogen peroxide-activated PARP in A549 human lung epithelial, C4I human cervical, and H9c2 rat cardiac myoblast cells with IC50 values of 229.09, 1,778.28, and 123.03 nM, respectively.Formal Name: 4-[(1-methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione. CAS Number: 1104546-89-5. Synonyms: PARP Inhibitor XIV. Molecular Formula: C15H12N2O2. Formula Weight: 252.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 427 nm. SMILES: O=C1NC(C(C=CC=C2)=C2/C1=C\C3=CC=CN3C)=O. InChi Code: InChI=1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9+. InChi Key: BTYSIDSTHDDAJW-UKTHLTGXSA-N.