BSJ-4-116

Item number	Size	Delivery time	Price
TGM-T9117-1mg	1 mg	7 - 10 business days*	49.00€
TGM-T9117-5mg	5 mg	7 - 10 business days*	112.00€
TGM-T9117-1mL	1 ml	7 - 10 business days*	172.00€
TGM-T9117-10mg	10 mg	7 - 10 business days*	187.00€
TGM-T9117-25mg	25 mg	7 - 10 business days*	395.00€
TGM-T9117-50mg	50 mg	7 - 10 business days*	636.00€
TGM-T9117-100mg	100 mg	7 - 10 business days*	952.00€

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Description: BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6... more

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Product information "BSJ-4-116"

Description: BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). Target: CDK, PROTACs. Smiles: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCN4C[C@H](NC=5N=C(NC6=C(S(C(C)C)(=O)=O)C=CC=C6)C(Cl)=CN5)CCC4)=O. References: Jiang B, et al. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021,17(6):675-683.

Supplier:	TargetMol
Supplier-Nr:	T9117

Properties

Application:	PROTAC, Cdk12 degradation
MW:	837.38 D
Formula:	C40H49ClN8O8S

Database Information

CAS :	2519823-34-6\| Matching products
KEGG ID :	K08819 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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