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BSJ-4-116
Item number: TGM-T9117-100mg
Description: BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). Target: CDK, PROTACs. Smiles:...
| Application: | PROTAC, Cdk12 degradation |
| CAS | 2519823-34-6 |
| MW: | 837.38 D |
From 49.00€
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BSJ-4-116
Item number: Cay39564-10
BSJ-4-116 is a proteolysis-targeting chimera (PROTAC) composed of a modified form of the multi-kinase degrader TL12-186 linked to the cereblon ligand and PROTAC synthetic intermediate E3 ligase ligand 2 (Cay-36664). It induces time- and concentration-dependent degradation of cyclin-dependent kinase 12 (Cdk12) in...
| Keywords: | N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6... |
| Application: | PROTAC, Cdk12 degradation |
| CAS | 2519823-34-6 |
| MW: | 837.4 D |
From 192.00€
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