Brivanib Alaninate

Brivanib alaninate is the L-alanine prodrug form of brivanib (Cay-23690), a VEGF receptor 2 (VEGFR2) and FGF receptor 1 (FGFR1) inhibitor. Brivanib alaninate (3 mg/kg per day) reduces hepatic angiogenesis and VEGF, TGF-beta1, CD31, and phosphorylated VEGFR2 and FGFR levels in a bile duct-ligated rat model of cirrhosis. It reduces tumor growth in an L2987 non-small cell lung cancer mouse xenograft model, exhibiting 97% tumor growth inhibition when administered at a dose of 107 mg/kg.Formal Name: L-alanine, (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl ester. CAS Number: 649735-63-7. Synonyms: BMS 582664. Molecular Formula: C22H24FN5O4. Formula Weight: 441.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 17 mg/ml, DMSO: 20 mg/ml, Ethanol: 12.5 mg/ml. lambdamax: 221, 240 nm. SMILES: C[C@@H](OC([C@@H](N)C)=O)COC1=CN2N=CN=C(OC3=CC=C(NC(C)=C4)C4=C3F)C2=C1C. InChi Code: InChI=1S/C22H24FN5O4/c1-11-7-15-16(27-11)5-6-17(19(15)23)32-21-20-13(3)18(8-28(20)26-10-25-21)30-9-12(2)31-22(29)14(4)24/h5-8,10,12,14,27H,9,24H2,1-4H3/t12-,14+/m1/s1. InChi Key: LTEJRLHKIYCEOX-OCCSQVGLSA-N.