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Brivanib Alaninate
Item number: Cay26081-5
Brivanib alaninate is the L-alanine prodrug form of brivanib (Cay-23690), a VEGF receptor 2 (VEGFR2) and FGF receptor 1 (FGFR1) inhibitor. Brivanib alaninate (3 mg/kg per day) reduces hepatic angiogenesis and VEGF, TGF-beta1, CD31, and phosphorylated VEGFR2 and FGFR levels in a bile duct-ligated rat model of...
| Keywords: | BMS 582664, L-alanine,... |
| Application: | VEGFR1/2 inhibitor prodrug |
| CAS | 649735-63-7 |
| MW: | 441.5 D |
From 174.00€
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Brivanib alinate
Item number: SYN-1135-M001
Soluble in DMSO or ethanol. Brivanib inhibitors VEGFR -2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM. Target: FGFR - VEGFR ,...
| Keywords: | BMS-582664 |
| Application: | VEGFR-2 / FGFR inhibitor |
| CAS | 649735-63-7 |
| MW: | 441,5 D |
From 223.00€
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Brivanib (alaninate)
Item number: TGM-T2576-5mg
Description: Brivanib Alaninate (BMS-582664) is the alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells,...
| Keywords: | BMS-582664, Brivanib Alaninate |
| Application: | Targets kinase insert domain protein receptor [EC:2.7.10.1] (KDR, VEGFR2, CD309) |
| CAS | 649735-63-7 |
| MW: | 441.46 D |
From 39.00€
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