BMS 986235

BMS 986235 is a formyl peptide receptor 2 (FPR2) agonist. It selectively induces calcium mobilization in HEK293 cells overexpressing human FPR2 over FPR1 (EC50s = 0.41 and 2,800 nM, respectively). BMS 986235 inhibits chemotaxis of HL-60 human promyeloblast cells and induces phagocytosis of opsonized zymosan by isolated mouse peritoneal macrophages. In vivo, BMS 986235 inhibits neutrophil infiltration into the lungs in a mouse model of LPS-induced lung inflammation. BMS 986235 reduces left ventricle remodeling, scar length, and heart mass in a mouse model of myocardial infarction when administered at a dose of 0.3 mg/kg on days 4-28 post-occlusion. It also reduces right and left ventricle damage and inflammation in a mouse model of Duchenne muscular dystrophy.. SMILES: O=C(NC1=CC=CC=C1)N[C@H]2[C@H](C3=C(C=C(C=C3F)OC)F)CNC2=O. InChi Code: InChI=1S/C18H17F2N3O3/c1-26-11-7-13(19)15(14(20)8-11)12-9-21-17(24)16(12)23-18(25)22-10-5-3-2-4-6-10/h2-8,12,16H,9H2,1H3,(H,21,24)(H2,22,23,25)/t12-,16-/m0/s1. InChi Key: FJZNNKJZHQFMCK-LRDDRELGSA-N