Bisantrene

Bisantrene is an inhibitor of fat mass and obesity-associated protein (FTO, IC50 = 142.6 nM in a cell-free assay). It decreases the viability of Mono-Mac-6, NOMO-1, U937, MV4-11, and ML-2 acute myeloid leukemia (AML) cells (IC50s = 58.9-175.9 nM), as well as increases the levels of N6-methyladenosine (m6A) in Mono-Mac-6 cells at 100 nM. Bisantrene induces apoptosis and cell cycle arrest at the G0/G1 phase in NOMO-1 cells. It induces ssDNA breaks and DNA-protein cross-links in L1210 skin lymphocytic leukemia cells when used at a concentration of 10 µg/ml. Bisantrene (5 mg/kg per day) decreases tumor growth and increases survival time in a patient-derived xenograft (PDX) mouse model of AML. Ex vivo, it induces primary mouse macrophage-mediated cytostasis of P815 mastocytoma cells when co-cultured after administration of a 100 mg/kg dose, an effect that can be inhibited by carrageenan.Formal Name: 9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] 9,10-anthracenedicarboxaldehyde. CAS Number: 78186-34-2. Synonyms: Bisantrenum. Molecular Formula: C22H22N8. Formula Weight: 398.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble: 0.1-1 mg/ml. SMILES: C1(C=NNC2=NCCN2)=C3C=CC=CC3=C(C=NNC4=NCCN4)C5=C1C=CC=C5. InChi Code: InChI=1S/C22H22N8/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30). InChi Key: NJSMWLQOCQIOPE-UHFFFAOYSA-N.