BIIB129

Item number	Size	Manual	Delivery time	Price
Cay43712-5	5 mg	-	6 - 10 business days*	123.00€
Cay43712-10	10 mg	-	6 - 10 business days*	232.00€
Cay43712-25	25 mg	-	6 - 10 business days*	547.00€
Cay43712-50	50 mg	-	6 - 10 business days*	852.00€

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BIIB129 is a covalent inhibitor of Bruton's tyrosine kinase (BTK). It is selective for BTK over a... more

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Product information "BIIB129"

BIIB129 is a covalent inhibitor of Bruton's tyrosine kinase (BTK). It is selective for BTK over a panel of 403 additional kinases at 1 µM. BIIB129 inhibits CD69 activation in isolated human whole blood (IC50 = 7.9 nM). In vivo, BIIB129 inhibits anti-myelin oligodendrocyte glycoprotein (MOG) antibody-induced microglia activation in mice (ED50 = 1.5 mg/kg). SMILES C[C@](C[C@H]1N(C)C(C=C)=O)(C1)OC2=NC(C(C=N3)=CN3C)=CN4C2=CC=N4 InChi Code InChI=1S/C19H22N6O2/c1-5-17(26)24(4)14-8-19(2,9-14)27-18-16-6-7-20-25(16)12-15(22-18)13-10-21-23(3)11-13/h5-7,10-12,14H,1,8-9H2,2-4H3/t14-,19+ InChi Key WBFSPPPOPIJCLF-DHFPXDALSA-N

Keywords:	N-methyl-N-[cis-3-methyl-3-[[6-(1-methyl-1Hpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy]cyclobutyl]-2-propenamide
Supplier:	Cayman Chemical
Supplier-Nr:	43712

Properties

Application:	Covalent BTK inhibitor
MW:	366.43 D
Formula:	C19H22N6O2
Purity:	>98%
Format:	Solid

Database Information

CAS :	2770960-52-4\| Matching products
KEGG ID :	K07370 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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