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Item number: Cay43712-10

BIIB129 is a covalent inhibitor of Bruton's tyrosine kinase (BTK). It is selective for BTK over a panel of 403 additional kinases at 1 µM. BIIB129 inhibits CD69 activation in isolated human whole blood (IC50 = 7.9 nM). In vivo, BIIB129 inhibits anti-myelin oligodendrocyte glycoprotein (MOG) antibody-induced...

Keywords:	N-methyl-N-[cis-3-methyl-3-[[6-(1-methyl-1Hpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy]cyclobutyl]-2-propenamide
Application:	Covalent BTK inhibitor
CAS	2770960-52-4
MW:	366.43 D

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