Befotertinib (mesylate)

Befotertinib is an inhibitor of mutant EGFRs. It selectively inhibits EGFRL858R, EGFRE709K, EGFRG719A, and EGFRL861Q (IC50s = 0. 14, 1. and 13 nM, respectively), as well as EGFR containing an exon 19 deletion and EGFR containing an exon 18 deletion (IC50s = 0. and 24 nM, respectively), over wild-type EGFR (IC50 = 360 nM). Formal Name: N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-[1-(2,2,2-trifluoroethyl)-1H-indol-3-yl]-2-pyrimidinyl]amino]phenyl]-2-propenamide, monomethanesulfonate. CAS Number: 2226167-02-6. Synonyms: D-0316. Molecular Formula: C29H32F3N7O2  CH3SO3H. Formula Weight: 663.7. Purity: >98%. Formulation (Request formulation change): A solid. Solubility: Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml. SMILES: FC(F)(F)CN1C=C(C2=NC(NC(C=C3NC(C=C)=O)=C(C=C3N(C)CCN(C)C)OC)=NC=C2)C4=CC=CC=C41.C[S](=O)(O)=O. InChi Code: InChI=1S/C29H32F3N7O2.CH4O3S/c1-6-27(40)34-22-15-23(26(41-5)16-25(22)38(4)14-13-37(2)3)36-28-33-12-11-21(35-28)20-17-39(18-29(30,31)32)24-10-8-7-9-19(20)24.1-5(2,3)4/h6-12,15-17H,1,13-14,18H2,2-5H3,(H,34,40)(H,33,35,36).1H3,(H,2,3,4). InChi Key: FFQDXZLQXPZZDJ-UHFFFAOYSA-N. Storage: -20°C. Stability: > 4 years.