BB-Cl-Amidine

BB-Cl-Amidine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17079-1 1 mg -

6 - 10 business days*

69.00€
Cay17079-5 5 mg -

6 - 10 business days*

173.00€
Cay17079-10 10 mg -

6 - 10 business days*

310.00€
 
BB-Cl-Amidine is a modified version of Cl-amidine (Cay-10599) that retains the functional... more
Product information "BB-Cl-Amidine"
BB-Cl-Amidine is a modified version of Cl-amidine (Cay-10599) that retains the functional components but possesses a C-terminal benzimidazole group designed to limit proteolysis of the C-terminal amide. BB-Cl-Amidine irreversibly inactivates all four PAD subtypes (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity. The cellular potency of BB-Cl-amidine against PAD4 is increased 20-fold over the parent compound (EC50 = 8.8 µM versus >200 µM for Cl-amidine). BB-Cl-Amidine also has a significantly longer in vivo half-life than Cl-amidine (1.75 h versus ~15 min, respectively). Both compounds inhibit the formation of neutrophil extracellular traps without altering H2O2 production by neutrophils. BB-Cl-Amidine is effective in vivo, improving endothelial function while downregulating the expression of type I interferon-regulated genes in MRL/lpr mice. Formal Name: N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide. CAS Number: 1802637-39-3. Molecular Formula: C26H26ClN5O. Formula Weight: 460.0. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 274, 281 nm. SMILES: O=C(N[C@@H](CCCNC(CCl)=N)C1=NC2=C(C=CC=C2)N1)C(C=C3)=CC=C3C4=CC=CC=C4. InChi Code: InChI=1S/C26H26ClN5O/c27-17-24(28)29-16-6-11-23(25-30-21-9-4-5-10-22(21)31-25)32-26(33)20-14-12-19(13-15-20)18-7-2-1-3-8-18/h1-5,7-10,12-15,23H,6,11,16-17H2,(H2,28,29)(H,30,31)(H,32,33)/t23-/m0/s1. InChi Key: YDOAWJHYHGBQFI-QHCPKHFHSA-N.
Keywords: N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide
Supplier: Cayman Chemical
Supplier-Nr: 17079

Properties

Application: PADI4 inhibitor
MW: 460 D
Formula: C26H26ClN5O
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 1802637-39-3| Find alternatives
KEGG ID : K24669 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P312, P303+P361+P353, P304+P340, P305+P351+P338, P337+P313, P370+P378, P405, P403+P235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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