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Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain,...

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. PADI4 antibody recognizes Protein-arginine deiminase type-4, a calcium-dependent enzyme that catalyzes the post-translational conversion of arginine residues to citrulline in target proteins. Protein-arginine deiminase type-4 is also widely referred to as PAD4...

1 mg/ml in 1X PBS, BSA free, sodium azide free. PADI4 antibody recognizes Protein-arginine deiminase type-4, a calcium-dependent enzyme that catalyzes the post-translational conversion of arginine residues to citrulline in target proteins. Protein-arginine deiminase type-4 is also widely referred to as PAD4 and...

Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain,...

Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively). It is without significant effect against PP2B, PP2C, and PP4. Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit...

Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain,...

Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain,...

BB-Cl-amidine is a pan inhibitor of peptidyl arginine deiminases (PADs) and a proteolysis-resistant derivative of Cl-amidine (Cay-10599). It irreversibly inhibits PAD1-4 (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1, respectively). BB-Cl-amidine (20 and 200 µM) inhibits the formation of neutrophil...

Cayman's PAD4 Inhibitor Screening Assay Kit (Ammonia) provides a convenient method for screening human PAD4 inhibitors. PAD4 deiminates N-alpha-benzoyl-L-arginine ethyl ester (BAEE), a non-natural substrate with similar kinetic properties to the natural substrates, producing ammonia.3 Ammonia reacts with a detector...

Citrulline is a non-proteinogenic amino acid that is produced by deimination of arginine through the post-translational modification citrullination. Citrullination is catalyzed by protein arginine deiminases (PADs) that convert positively charged arginine to electrically neutral citrulline, decreasing the...

Cayman's PAD4 Autoantibody High-Sensitivity ELISA Kit is an immunometric assay that can be used to measure IgG, IgM, or IgA isotypes of PAD4 autoantibodies in human plasma and serum without prior sample purification., , The levels of PAD4 autoantibodies in samples can be estimated using a standard curve. Please...

Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is expressed in neutrophils, as well as a variety of tissues, including the brain,...