(±)-Baclofen

(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM). It induces norepinephrine release from isolated rat atria (IC50 = 4.5 µM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice. It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats. (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice. Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.Formal Name: beta-(aminomethyl)-4-chloro-benzenepropanoic acid. CAS Number: 1134-47-0. Molecular Formula: C10H12ClNO2. Formula Weight: 213.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 4 mg/ml. lambdamax: 220, 266 nm. SMILES: ClC1=CC=C(C(CN)CC(O)=O)C=C1. InChi Code: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14). InChi Key: KPYSYYIEGFHWSV-UHFFFAOYSA-N.