(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM). It induces norepinephrine release from isolated rat atria (IC50 = 4.5 µM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice. It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats. (±)-Baclofen also reduces...

Baclofen is a GABA-b receptor agonist.

Description: Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing...

(±)-Baclofen (Cay-27326) is an analytical reference standard categorized as a gabapentinoid and a nootropic. (±)-Baclofen also has analgesic, skeletal muscle relaxant, and sedative properties. Formulations containing (±)-baclofen have been used in the treatment of spasticity in patients with multiple sclerosis or...

Specific GABA-B receptor agonist. Muscle relaxant (skeletal). Melting Point: 206-208°C , Storage and Stability:, May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.