Azasetron (hydrochloride)

Azasetron is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 2.9 nM). It is selective for 5-HT3 over 5-HT1A and 5-HT2 (IC50 = >10 µM for both), as well as dopamine D1 and D2 and alpha1- and alpha2-adrenergic receptors (IC50s = >10 µM), but it does bind to histamine H1 receptors (IC50 = 4.4 µM). Azasetron inhibits contractions induced by 5-HT (Cay-14332) in isolated guinea pig ileum (pA2 = 7.04) and isolated rabbit heart (pA2 = 10.06). It inhibits emesis induced by cisplatin (Cay-13119) in dogs and induced by doxorubicin (Cay-15007) combined with cyclophosphamide (Cay-13849) in ferrets when administered at a dose of 1 mg/kg.Formal Name: N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide, monohydrochloride. CAS Number: 123040-16-4. Synonyms: Y-25130. Molecular Formula: C17H20ClN3O3 . HCl. Formula Weight: 386.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 221, 307 nm. SMILES: O=C(C1=C(OCC(N2C)=O)C2=CC(Cl)=C1)NC3C4CCN(CC4)C3.Cl. InChi Code: InChI=1S/C17H20ClN3O3.ClH/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21,/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23),1H. InChi Key: DBMKBKPJYAHLQP-UHFFFAOYSA-N.