Avanbulin

Avanbulin is an inhibitor of microtubule polymerization and is the active metabolite of the lysine-containing prodrug lisavanbulin. Avanbulin binds to unassembled tubulin at the binding site for colchicine (Cay9000760) and inhibits tubulin assembly (IC50 = 1.4 µM). It is cytotoxic to GBM6 and GBM9 glioblastoma cells (EC50s = 20.8 and 21.7 nM, respectively). Avanbulin (6 nM) reduces migration and capillary-like structure formation in GBM6 cells in a manner dependent on end-binding protein 1 (EB1).. SMILES: N#CCCNC1=NON=C1C2=NC3=CC=CC=C3N2CC(C4=CC=C(C=C4)N)=O. InChi Code: InChI=1S/C20H17N7O2/c21-10-3-11-23-19-18(25-29-26-19)20-24-15-4-1-2-5-16(15)27(20)12-17(28)13-6-8-14(22)9-7-13/h1-2,4-9H,3,11-12,22H2,(H,23,26). InChi Key: LSFOZQQVTWFMNS-UHFFFAOYSA-N