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Item number: Cay45297-10

Avanbulin is an inhibitor of microtubule polymerization and is the active metabolite of the lysine-containing prodrug lisavanbulin. Avanbulin binds to unassembled tubulin at the binding site for colchicine (Cay9000760) and inhibits tubulin assembly (IC50 = 1.4 µM). It is cytotoxic to GBM6 and GBM9 glioblastoma cells...

Keywords:	3-[[4-[1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-yl]amino]-propanenitrile
Application:	Microtubule polymerization inhibitor, antineoplastic
CAS	798577-91-0
MW:	387.4 D

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Avanbulin

Item number: TGM-T21317-1mL

Description: Avanbulin is a potent inhibitor of tubulin polymerization with antitumor activity. It elicits a unique microtubule (MT) phenotype, distinct from colchicine, paclitaxel, and vinblastine has broad in vitro anti-proliferative activity against a diverse range of human tumor lines at low nM IC50s. Target:...

Keywords:	BAL 27862, BAL-27862, BAL27862
CAS	798577-91-0
MW:	387.39 D

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