AT-001

AT-001 is an inhibitor of aldose reductase (IC50 = 28.9 pM). It reduces infarct area in streptozotocin-induced diabetic mice expressing human aldose reductase in a model of cardiomyopathy induced by ischemia-reperfusion injury when administered at a dose of 40 mg/kg.Formal Name: 7,8-dihydro-8-oxo-7-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-pyrazino[2,3-d]pyridazine-5-acetic acid. CAS Number: 1355612-71-3. Synonyms: Caficrestat. Molecular Formula: C17H10F3N5O3S. Formula Weight: 421.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 221, 257 nm. SMILES: O=C(CC1=NN(CC2=NC3=C(S2)C=CC(C(F)(F)F)=C3)C(C4=NC=CN=C41)=O)O. InChi Code: InChI=1S/C17H10F3N5O3S/c18-17(19,20)8-1-2-11-9(5-8)23-12(29-11)7-25-16(28)15-14(21-3-4-22-15)10(24-25)6-13(26)27/h1-5H,6-7H2,(H,26,27). InChi Key: YRGPAXAVTDMKDK-UHFFFAOYSA-N.