AS-252424

AS-252424
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009052-1 1 mg -

6 - 10 business days*

39.00€
Cay10009052-5 5 mg -

6 - 10 business days*

107.00€
Cay10009052-10 10 mg -

6 - 10 business days*

194.00€
Cay10009052-25 25 mg -

6 - 10 business days*

437.00€
 
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to... more
Product information "AS-252424"
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kgamma is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kalpha, beta, and delta are class 1A enzymes composed of p110 and p85 subunits. AS-252424 is a potent inhibitor of phosphatidylinositol-3-kinase PI3K with selectivity for the gamma isoform. It inhibits human recombinant PI3Kgamma, alpha, beta, and delta with IC50 values of 30, 940, 20,000 and 20,000 nM, respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 value of 0.23 µM. In a murine model of peritonitis, AS-252424 inhibited neutrophil recruitment 35% at a dose of 10 mg/kg. Formal Name: 5-[5-(4-fluoro-2-hydroxy-phenyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione. CAS Number: 900515-16-4. Molecular Formula: C14H8FNO4S. Formula Weight: 305.3. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 408 nm. SMILES: O=C(N([H])C(S/1)=O)C1=C\C2=CC=C(C3=C(O)C=C(F)C=C3)O2. InChi Code: InChI=1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6-. InChi Key: OYYVWNDMOQPMGE-SDQBBNPISA-N.
Keywords: 5-[5-(4-fluoro-2-hydroxy-phenyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione
Supplier: Cayman Chemical
Supplier-Nr: 10009052

Properties

Application: PI3K inhibitor
MW: 305.3 D
Formula: C14H8FNO4S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 900515-16-4| Find alternatives
KEGG ID : K00922 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300, H315, H318, H361, H372
P Phrases: P201, P202, P260, P264, P270, P280, P301+310, P302+352, P305+351+338, P308+313, P310, P314, P321, P330, P332+313, P362+364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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