Description: AS-252424 is a potent and selective inhibitor of PI3Kgamma with an IC50 of 33 nM and demonstrates over 10-fold selectivity for PI3Kgamma versus PI3Kalpha. Target: Casein Kinase, PI3K. Smiles: Oc1cc(F)ccc1-c1ccc(\C=C2/SC(=O)NC2=O)o1. References: Pomel V, et al, J Med Chem, 2006, 49(13), 3857-3871.

AS-252424 is a potent inhibitor of phosphatidylinositol-3-kinase PI3K with selectivity for the gamma isoform. It inhibits human recombinant PI3Kgamma, alpha, beta, and delta with IC50 values of 30, 940, 20,000 and 20,000 nM, respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7...

AS-252424 is an inhibitor of p110 PI3K that exhibits anti-inflammatory activity. In animal models of peritoneal inflammation, AS-252424 decreases leukocyte recruitment. In vascular smooth muscle cells, AS-252424 decreases endothelin A receptor-mediated activity of transient receptor potential canonical 1/5/6...

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AS-252424 is a potent and selective PI3K inhibitor. It inhibits human recombinant PI3K alpha, beta, gamma and delta with IC(50) values of 30, 940, 20.000, and 20.000nM respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid