Alpelisib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Alpelisib (BYL-719) is a PI3Kalpha inhibitor (IC50=5 nM) with selective, potent, and... more
Product information "Alpelisib"
Description: Alpelisib (BYL-719) is a PI3Kalpha inhibitor (IC50=5 nM) with selective, potent, and oral activity, inhibiting PI3Kbeta/gamma/delta with low activity (IC50=250/290/1200 nM). Alpelisib demonstrates antitumor activity and specifically targets PIK3CA mutant tumors. Target: PI3K. Smiles: Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(c1)C(C)(C)C(F)(F)F. References: Gobin B, et al. BYL719, a new alpha-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma. Int J Cancer. 2015 Feb 15,136(4):784-96.
| Keywords: | BYL-719 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1921 |
Properties
| Application: | Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta |
| MW: | 441.47 D |
| Formula: | C19H22F3N5O2S |
Database Information
| CAS : | 1217486-61-7| Matching products |
| KEGG ID : | K00922 | Matching products |
| Protein Atlas Nr. : | Lipid / Phosphoinositial Signaling |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H373 |
| P Phrases: | P260, P314, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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